ALLERGIES Food Allergy

Grape Allergy: Symptoms, Causes, Treatment, and More


A grape allergy refers to an immune system reaction to proteins present in grapes. It is a type of food allergy that occurs and is not common. In the United States, it is estimated that food allergies affect around 4-6% of adults and 5-8% of children.

Grapes are delicious and eaten after lunch or dinner as a sweet dish, but some people sometimes overeating grapes can cause a grapes allergy. The allergic reaction can be mild or severe as well. But if the symptoms are severe, it can also cause the death of any affected person.

An allergy occurs when the immune system mistakenly identifies proteins in grapes as harmful. In return, it triggers the release of histamine and other chemicals in the body. This leads to various symptoms, including itching, hives, swelling, etc.

Grape allergy is different from grape intolerance, which is a digestive issue. Intolerance is caused by the inability to properly metabolize compounds in grapes.

Grape allergy is an adverse reaction to grapes or any product that contains grapes. The severity of symptoms can vary from person to person. Some people experience only mild symptoms, while others may have a severe reaction.

A man holding grapes in hand giving the concept of grape allergy.

Grape Allergy Symptoms

Symptoms can occur immediately after eating the fruit of the grape. While some people may also develop an allergy to grapes later in life, after regularly consuming the fruit without a problem. The symptoms of a grape allergy can range from mild to severe and may include:

  • Itching or tingling in the mouth
  • Hives or skin rash
  • Stomach pain
  • Nausea
  • Vomiting
  • Diarrhea
  • Abdominal cramps
  • Swelling of the face, lips, tongue, or throat

In severe cases, a grape allergy can cause anaphylaxis, a life-threatening reaction. The symptoms may include:

  • Shortness of breath
  • Difficulty breathing
  • Rapid pulse
  • A sudden decrease in blood pressure
  • Unconsciousness

If you suspect you have a grape allergy, it is important to see an allergist for proper diagnosis and treatment. An allergist can also advise you on how to avoid grapes and grape-containing products.

Causes of Grape Allergy

Grape allergy is a reaction that occurs when your body’s immune system mistakes grapes for a harmful substance and reacts to it.

The allergy can cause by a protein found in grapes that triggers an immune response. When you consume grapes or products made from grapes, your body releases histamine. This causes symptoms such as itching, hives, swelling, and difficulty breathing.

It’s important to note that this allergy can be different from wine intolerance. Intolerance is a digestive reaction to the alcohol in wine, and not an immune response. It is also different from sulfite sensitivity, which is a reaction to the sulfites used as a preservative in some wines.

Grape Allergy and Cross-reactivity

Cross-reactivity refers to the chance of having an allergic reaction to a food that is similar to another food that you are already allergic to.

If you have a grape allergy, there is a chance that you may also be allergic to other fruits. These includes:

This is because these fruits have similar proteins to grapes. It can cause an allergic reaction in people who are sensitive to grapes.

It is important to note that cross-reactivity is not always present and can vary from person to person. If you have sensitivity to grapes, it is recommended to contact an allergist. This will help to determine if you should avoid other fruits as well.

Diagnosis of Grapes Allergy

Diagnosis of Grape Allergy is a process that helps identify if a person is allergic to grapes. A proper diagnosis is important for the best treatment and management of the allergy. There are several methods used to diagnose it, including:

A. Medical History and Physical Examination:

The doctor will ask questions about the symptoms experienced after consuming grapes. He will examine the skin for any signs of an allergic reaction.

B. Skin Prick Test:

This test involves pricking the skin with a small amount of grape extract. After that, need to observe if there is a reaction, such as redness, itching, or swelling.

C. Blood Test:

This test measures the level of specific antibodies in the blood. These antibodies are associated with an allergic reaction to grapes.

D. Oral Food Challenge Test:

This is considered the most reliable test for diagnosing grape allergy. The person will consume a small number of grapes under close supervision. After it, the doctor will check for any allergic reactions.

It’s important to see an expert allergist for the proper diagnosis and treatment. With the right care, sensitive people can manage their condition and enjoy a healthy lifestyle.

Treatment of Grapes Allergy

The best treatment for grapes allergy is to avoid eating grapes. You need to avoid all other products in which grapes are present. If avoiding grapes and grape products is not enough to manage your symptoms.

There are some over-the-counter antihistamines and medications that can help. These can be used to reduce symptoms such as itching, hives, and sneezing.

If the symptoms are severe then it is best to carry epinephrine every time to relieve severe allergic symptoms. If you suspect you are having an anaphylactic reaction, seek medical help immediately.

What to avoid?

Identifying and avoiding allergenic foods is important for people with a grape allergy.  If you suspect, you have an allergy it’s important to avoid grapes and products that contain grapes. This may include:

  • Checking food labels
  • Avoiding certain types of wine or juice and
  • Asking questions when eating out

By following these steps, you can help manage your allergy and live a healthy life. Here is list of some foods you need to avoid in order to manage your allergy symptoms.

  • Grapes
  • Wine
  • Raisins
  • Grape juice, sauce, and flavoring
  • Grape seed oil
  • Vinegar (sometimes made from grapes)
  • Grape extracts
  • Fruit punch and fruit cocktails
  • Dried fruit mixes
  • Fruit preserves and jams
  • Fruit leather
  • Baked goods containing grape juice or grapes.
  • Salad dressings containing grape juice or grapes
  • Snack bars with dried grapes or grape juice
  • Processed foods containing grape ingredients.


If you think you are suffering from a grapes allergy, then stop eating the grapes immediately. And get an appointment with the doctor or allergist. Let the allergist know in detail. About the symptoms, you are experiencing and describe the time also.

From which you are experiencing the symptoms. So that the allergist can diagnose the cause of the allergic reaction, don’t hesitate to tell the allergist anything. You must get immediate proper treatment from the nearby hospital if you have severe allergic symptoms.

To get relief, follow the prescription by the allergist. If you don’t follow the prescription, there are more chances of rising the reaction again, which will be dangerous for your health. 

Severe allergic symptoms can also cause the death of an affected person. So, you must be careful in following the prescription given to you by the allergist. Cut the grapes from your diet. And use the alternative of grapes in your diet to recover from any deficiency in the body.


What causes grape allergies?

Vit v 1, a Lipid Transfer Protein, is the main allergen in grapes (LTP). These heat-resistant proteins are present in a wide variety of plants.

Why do grapes cause hives in me?

Grape contains thaumatin, a protein similar to the cherry thaumatin-like allergen. It may cause cross-reactivity with other foods that contain this pan allergen.